Dual roles of brushite crystals in calcium oxalate crystallization provide physicochemical mechanisms underlying renal stone formation
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چکیده
منابع مشابه
Thiazides reduce brushite, but not calcium oxalate, supersaturation, and stone formation in genetic hypercalciuric stone-forming rats.
Over 59 generations, a strain of rats has been inbred to maximize urine calcium excretion. The rats now excrete eight to 10 times as much calcium as controls. These rats uniformly form calcium phosphate (apatite) kidney stones and have been termed genetic hypercalciuric stone-forming (GHS) rats. The addition of a common amino acid and oxalate precursor, hydroxyproline, to the diet of the GHS ra...
متن کاملCatechin prevents the calcium oxalate monohydrate induced renal calcium crystallization in NRK-52E cells and the ethylene glycol induced renal stone formation in rat
BACKGROUND Reactive oxygen species play important roles in renal calcium crystallization. In this study, we examined the effects of catechin, which have been shown to have antioxidant properties on the renal calcium crystallization. METHODS In the vitro experiment, the changes of the mitochondrial membrane potential, expression of superoxide dismutase (SOD), 4-hydroxynonenal (4-HNE), cytochro...
متن کاملProtein-crystal Interactions in Calcium Oxalate Kidney Stone Formation
We have studied the ability of urinary molecules in altering the precipitation of kidney stone-related calcium oxalate monohydrate (COM) crystals and correlated the resulting morphologies with those of idiopathic COM kidney stones. We found that weakly acidic but highly glycosylated polyelectrolytes (Tamm Horsfall protein (THP), fetuinA, hyaluronic acid) do not significantly affect crystallizat...
متن کاملEffect of High Osmotic Pressure Milk Formula on Renal Calcium Oxalate Crystallization Induced by Calcium Oxalate
To study the effect of high osmotic pressure milk formula on renal calcium oxalate crystallization induced by calcium oxalate. 40 SD rats were randomly divided into four groups: NC, MC, LOM and HOM group. For model preparation, MC, LOM and HOM were treated with 1% Ethanediol in the water combined with 2% ammonium chloride (2ml/day) intragastrically administration. The rats in LOM and HOM were i...
متن کاملRenal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both.
Although often supersaturated with mineral salts such as calcium phosphate and calcium oxalate, normal urine possesses an innate ability to keep them from forming harmful crystals. This inhibitory activity has been attributed to the presence of urinary macromolecules, although controversies abound regarding their role, or lack thereof, in preventing renal mineralization. Here, we show that 10% ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2006
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5000424